This topic explores the pivotal role of Small and Medium-sized Enterprises (SMEs) as engines of economic growth and innovation in both the United States and Africa. This panel will delve into actionable strategies aimed at unlocking the full potential of SMEs and bolstering their participation in bilateral trade and investment. From streamlining regulatory frameworks to enhancing access to finance and market opportunities, panelists will discuss pragmatic approaches to overcome barriers hindering SMEs' expansion into internet leaders, policymakers, and industry experts who will share best practices, success stories, and innovative solutions for turbocharging SMEs. By highlighting the significance of SMEs as catalysts for economic transformation, this session aims to inspire collaborative action and catalyze initiatives that propel SMEs to the forefront of U.S.-Africa trade and investment, ultimately fostering sustainable growth and prosperity on both continents.