Women’s Economic Empowerment (WEE) acts as a transformative force in enhancing U.S.-Africa trade, investment, and business. By breaking down barriers and fostering gender-inclusive policies, women's participation drives economic growth, innovation, and resilience in both regions. Investing in women-owned businesses not only promotes social equality but also fuels job creation, poverty reduction, and community development, making it a strategic imperative for fostering impactful trade relations between the United States and Africa. This topic will delve into strategies to collaborate on Women's Economic Empowerment initiatives in the private and public sectors, with a specific emphasis on fostering partnerships in the context of US-Africa trade and investment. From advocacy to capacity building and skills development to technology and innovation initiatives, this plenary discussion will explore ways to create conducive environments for women entrepreneurs and professionals, leveraging the strengths of both public and private sectors collectively to drive sustainable economic growth, innovation, and inclusivity.