In recent years, there has been a growing recognition of the pivotal role that women play in driving economic growth and development, particularly as women-owned enterprises and traders play prominent roles in Africa, the United States and around the globe. The U.S.-Africa economic relationship presents a tremendous opportunity to leverage the power of women's leadership and entrepreneurship. This plenary session aims to explore the challenges, opportunities, and best practices in promoting and enhancing women’s role in intra-African trade well as Africa’s trade with global partners such as the United States. Panelists and experts will discuss both public and private sector initiatives, including those of international organizations and foundations, that address women's participation in trade and investment activities, will showcase success stories and highlight the transformative impact of women's leadership in driving trade and investment. Policy measures and interventions to promote gender equality and women's leadership in trade and investment will be highlighted as critical to Africa’s economic growth and to a stronger U.S.-Africa trade, investment, and commercial relationship.